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Drug: Actiq

fentanyl transmucosal (pronounced FEN-tuh-nil)

 
Common Side Effects: sedation, extreme sleepiness, disorientation, euphoria, low blood pressure, nausea, vomiting, constipation, dry mouth, itching, sweating, difficulty urinating.
 
Less Common Side Effects: dizziness, headache, confusion, weakness, nervousness, hallucinations, anxiety, depression, high blood pressure, chest pain, obstruction of the bowel, stomach pain, poor appetite, diarrhea, heart pain, slow breathing, shortness of breath, apnea, reaction at application site (redness, papules, swelling), physical dependence.
 
Missed Dose: This medication is taken as needed at the first sign of breakthrough pain. It isn't likely that you'll miss a dose.

Remove the foil overwrap and place the lozenge between your cheek and gum for about 15 minutes. You may occasionally move the lozenge from side to side using the stick. Don't chew the lozenge.

If the pain isn't relieved, you may take a second lozenge 15 minutes after you finish the first (30 minutes after you have placed the first lozenge in your mouth). If you have several episodes of breakthrough pain that require two lozenges, contact your health care provider. Your dose may need to be increased. You should take no more than four lozenges daily.

 
Drug Interactions: Combining certain medications may alter their actions or produce unwanted effects. Tell your health care provider about other prescription medications, nonprescription medications, herbs, and supplements you're taking, especially:
  • clarithromycin (Biaxin)
  • diazepam
  • erythromycin
  • hypnotics
  • itraconazole (Sporanox)
  • ketoconazole (Nizoral)
  • MAO inhibitors (antidepressants)
  • medications that slow down the central nervous system (such as cold and allergy medications, tranquilizers, and sedatives)
  • nefazodone
  • nelfinavir (Viracept)
  • other opioid analgesics
  • ritonavir (Norvir)
  • sedatives
  • tricyclic antidepressants (such as amitriptyline and desipramine).
  • troleandomycin
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